CALCRL and Myocardial fibrosis: Zhang et al. [39] investigated the proteolytic cleavage product of prepro-IMD, designated IMD1–53, and demonstrated its non-selective binding and activation of the calcitonin receptor-like receptor (CRLR)/receptor activity modifying protein (RAMP) complexes to induce cAMP/PKA activation, which in turn inhibited inositol-requiring enzyme 1α (IRE1α) and NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome activation, thereby attenuating inflammatory cytokines and ameliorating Angiotensin II (AngII)-induced myocardial fibrosis in rat models.