In this study, we investigated the presence of possible correlations, at the transcript level, between 13 S100 genes (S100A2, S100A4, S100A6, S100A7, S100A8, S100A9, S100A10, S100A11, S100A12, S100A13, S100A14, S100A16 and S100P) and HMGB, in a cDNA array of 19 pancreatic tumors, and in 8 well-characterized human cancer cell lines (AsPC-1, BxPC-3, Capan-2, CFPAC-1, HPAF-II, Hs 766T, MIA PaCa-2, and PANC-1). This evidence concerns the gene S100B and cancer.