When Aβ-induced memory deficits became evident, 15 days after Aβ-icv, A2AR density was still larger (p = 0.012, Student’s t test) in synaptosomal membranes from Aβ-icv treated (35.4 ± 3.4 fmol/mg protein, n = 6) compared to vehicle-treated mice (22.8 ± 1.8 fmol/mg protein, n = 6) (Figure 3A), but there was no significant difference (p = 0.175, Student’s t test) between the binding density of A2AR in total membranes from Aβ-icv-treated (13.0 ± 1.5 fmol/mg protein, n = 5) compared to vehicle-treated mice (10.2 ± 0.9 fmol/mg protein, n = 6) (Figure 3A). This evidence concerns the gene ADORA2A and memory.