ADORA2A and Alzheimer disease: The effects of A2AR in the control of abnormal synaptic plasticity likely reflect the key role of A2AR in the control of memory dysfunction, as heralded by the previous observations that A2AR activation is sufficient to trigger memory dysfunction [27,28,29], whereas A2AR blockade dampens memory dysfunction in AD models [8,22,25,32,33,34,41], specifically in the currently used Aβ-icv model of AD [25,41,52].