Furthermore, A2AR blockade reverted the deficits of synaptic plasticity in a manner similar to that previously reported in the normalization of abnormal synaptic plasticity in the hippocampus in different animal models of AD [8,22,32,33,41] and those of other brain diseases [24,26,42,44,79,80,81,82,83]. This evidence concerns the gene ADORA2A and brain disorder.