ADORA2A and Alzheimer disease: Notably, the pharmacological, genetic or optogenetic overfunction of A2AR is actually sufficient to deteriorate behavioral performance in tests of spatial reference memory [22,27,28,29], and, conversely, the pharmacological or genetic blockade of A2AR afford a general neuroprotection against brain damage (reviewed in [14,30,31]) and prevent memory dysfunction in different animal models of AD [8,22,25,32,33,34].