The TAR DNA-binding protein 43 (TDP-43) is another example of a misfolded protein implicated in a number of neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and limbic-predominant age-associated TDP-43 encephalopathy (LATE) [61]. Here, TARDBP is linked to amyotrophic lateral sclerosis.