PPP2R5D and hereditary elliptocytosis: For this purpose, 2-week-old wildtype Ppp2r5d +/+ (WT), heterozygous Ppp2r5d +/− (HE), and homozygous Ppp2r5d −/− (HO) mice were injected with DEN, and tumor development was followed up to 11 months post-DEN injection.