We identified that epidermal MMP-13 upregulation with paclitaxel treatment causes extracellular matrix degradation and axon degeneration and showed that MMP-13 is a conserved mediator of paclitaxel-induced peripheral neuropathy since its pharmacological inhibition prevents cutaneous axon degeneration in zebrafish, mouse, and rat models [19,20]. Here, MMP13 is linked to peripheral neuropathy.