MMP13 and osteoarthritis: Of the upregulated collagens, COL2A1 has been previously demonstrated to be a substrate for MMP-13 in osteoarthritis (OA) [40] and has been suggested as a disease biomarker [41] (COL2A1: CTRL005: 10.14 TPM; CTRL006: 15.30 TPM; CTRL007: 8.34 TPM versus CIPN001: 38.58 TPM; CIPN002: 90.260; CIPN003: 58.19 TPM; logFC: 2.42).