Functional assays showed that these miRNAs exerted antitumor functions in BrCa cells by controlling several genes closely involved in BrCa malignant transformation, e.g., TRIP13, CCNB1, RAD51, PSPH, CENPN, KPNA2, and MXRA5. The gene discussed is CCNB1; the disease is invasive breast carcinoma.