Additionally, in a study investigating the protective effects of extracellular vesicles in premature infant urine against cisplatin-induced acute kidney injury, researchers found that miR-30a-5p, the most abundant miRNA in premature infant urine-derived extracellular vesicles, can target and downregulate mitogen-activated protein kinase 8 (MAPK8) to protect HK-2 cells from cisplatin-induced apoptosis [152]. This evidence concerns the gene MAPK8 and acute kidney injury.