CircBCL2 (intronic) was upregulated in ETV6-RUNX1 fusions (p = 0.0166), circSETBP1 and circX (intergenic) were significantly reduced in MLL rearranged samples (p = 0.0274 and p = 0.0472, respectively), and circIKZF1 was lower in BCP-ABL and hyperdiploid leukemias than in the ETV6-RUNX1 subtype (p = 0.0154), in which the expression was conserved at levels comparable to B-cells. Here, RUNX1 is linked to leukemia.