A recent study revealed that PRMT2 could induce HCC tumorigenesis through Bcl2 activation [30], which substantiates the notion that PRMT2 plays an influential role in driving HCC development, as evidenced by the significant upregulation observed in stages II and III/V compared with stage I. In this case, it is plausible to postulate that PRMT2′s impact might be predominantly confined to the early stages of HCC tumorigenesis, with limited or even counteractive influences on the later stages regulated by complex mechanisms. Here, PRMT2 is linked to hepatocellular carcinoma.