Although the cohort of TNM stages III + IV HCC was insufficient to draw definitive conclusions, the current results demonstrated a certain association between high expression of PRMT1, PRMT3, PRMT4, PRMT5, and PRMT6 and poor survival rates (Figure 4B), with PRMT1 and PRMT5 showing notable effects, while no significant correlation was observed for other PRMTs. This evidence concerns the gene PRMT5 and hepatocellular carcinoma.