Subcutaneous mouse hPD-L1 knock-in synergic tumour model with intra-tumoural OV injection:Survival: significantly prolonged survival compared to untreatedDisease control: significantly decreased tumour growth compared to untreated successful tumour rejection following rechallengeImmune response: significant systemic increase in total number of CD8+ effector memory and CD8/CD4+ central memory T cells. The gene discussed is CD4; the disease is neoplasm.