Bilateral subcutaneous mouse xenograft tumour model with intra-tumoural OV injection in humanised PD-1 transgenic mice:Disease control: significantly decreased tumour growth compared to untreated and parental OVImmune response: significantly increased tumour CD4+ and CD8+ T cell infiltration compared to untreated; RNA-seq analysis demonstrated significant enrichment in anti-viral, IFN and antigen presentation and processing pathways compared to untreated. This evidence concerns the gene CD4 and neoplasm.