A recent study analyzing the COG trial cohorts showed poor outcomes of not only NUP98::NSD1 and NUP98::KDM5A cases but of cases with other NUP98-fusion-positive AML (unlike NSD1 and KDM5A cases, other NUP98-fusions are typically not cryptic) [44]. Here, NSD1 is linked to acute myeloid leukemia.