Current research categorizes these molecular subtypes into six major classes: (i) hormone-receptor-positive breast cancer (ER+), (ii) hormone receptor/HER2-positive breast cancer (ER+/HER2+), (iii) HER2-positive breast cancer (HER2+), (iv) basal-like breast cancer, (v) claudin-low subtype, and (vi) normal-like subtype [5]. The gene discussed is ESR1; the disease is breast cancer.