In patients with localized PCa receiving neoadjuvant androgen deprivation therapy and radiotherapy, we explore the existence of putative prostate region-wise imaging biomarker (radiomic, diffusion, and/or perfusion features) profiles extracted from MRIs in order to discriminate patients according to their risk or the appearance of BCR 10 years after diagnosis, as well as to determine their predictive value alone or in combination with clinical variables. This evidence concerns the gene BCR and posterior cortical atrophy.