This specific arrangement depending at least on the CDKN2A promoter and 3 CTCF binding sequences within CDKN2B exon-1, ARF exon-1b, and CDKN2A exon-3 is likely to play a critical role in regulating the expression of the CDKN2A/ARF, CDKN2B, ANRIL genes in HUVEC cells and in the colon-cancer-related cell lines GES1, BGC823 and H1299 [50,52,53]. This evidence concerns the gene CDKN2B and malignant colon neoplasm.