Finally, in the context of colon cancer, when HCT-8 and HCT116 cells were treated with Qingjie Fuzheng Granule (QFG), it was found that ANRIL expression decreased together with TGF-β1, phosphorylated (p)-SMAD2/3, SMAD4, and N-cadherin reduction [67]. Here, CDKN2B-AS1 is linked to malignant colon neoplasm.