Moreover, the interactions between ANRIL and let-7 miRNA (7a, 7b-5p), miR-122-5p and miR-181a have been shown to increase cancer stem cell proliferation and epithelial–mesenchymal transition (EMT) by affecting multiple pathways including Wnt, NOTCH, STAT3/NF, MAPK/ERK, PI3K/AKT, and glycolysis in BrC, OC, TC, CR and HNSCC [106,116,120,151,152,224]. The gene discussed is CDKN2B-AS1; the disease is cancer.