Since its first association with pathologies in 2007 [31], the 9p21 locus have been the topic of several genome-wide association studies (GWAS), unveiling ANRIL sequences as a hotspot for single nucleotides polymorphisms (SNPs) that are susceptibility factors for several pathologies such as CVD, T2D and cancers [163,164]. This evidence concerns the gene CDKN2B-AS1 and type 2 diabetes mellitus.