Overexpression of immune checkpoint molecules, such as programmed death-1 (PD-1), cytotoxic T-lymphocyte antigen 4 (CTLA-4), lymphocyte-activating gene 3 protein (LAG-3), and mucin domain molecule 3 (TIM-3), on both tumor and immune cells, paired with elevated levels of immunosuppressive cytokines, impedes T cell activity, facilitating HCC’s evasion of the immune response [9]. The gene discussed is LAG3; the disease is hepatocellular carcinoma.