Compared with RPMI-8226 parental cells, melphalan-resistant MM cell line LR5 cells have elevated expression of genes involved in the FA/BRCA pathway, such as BRCA1, BRCA2, FANCA, FANCC, FANCD2, FANCF, and RAD51, leading to reduced formation of ICLs and enhanced ICL removal [53]. Here, BRCA2 is linked to Miyoshi myopathy.