Commonly reported grade ≥ 3 toxicities included the following: hypertension (20–22%), increased alanine aminotransferase (ALT; 11–16%), increased aspartate aminotransferase (AST; 9–13%), hyponatremia (6–8%), diarrhea (6%), and QT interval prolongation on electrocardiogram (5%) [37,84,142]. The gene discussed is GPT; the disease is Hypertension.