RET and colorectal adenocarcinoma: In their study, Kato et al. identified other canonical activating RET mutations, including V804M (n = 4) and C634R (n = 2), which involved cases of breast carcinoma (C634R) or gastrointestinal malignancies (V804M) such as colorectal adenocarcinoma, gastrointestinal stromal tumor, or hepatocellular carcinoma [47].