In another study, a mesoporous silica nanoparticle (MSNP) carrier system loaded with gemcitabine and paclitaxel demonstrated improved efficacy of gemcitabine due to the dual effect of paclitaxel in inducing tumor stroma suppression and inhibiting the expression of the GEM-inactivating enzyme cytidine deaminase (CDA) in a PANC-1 orthotopic model [261]. Here, CDA is linked to neoplasm.