For this reason, in addition to HEK293 cells, we performed a proteomic screen in HKe-3 cells, a colorectal cancer cell line derived from HCT116 cells where the oncogenic KRASG13D allele was knocked out that tolerates overexpression of KRAS mutants and we used before to perform proteomics screens [44,45]. This evidence concerns the gene KRAS and colorectal cancer.