KLK3 and Familial prostate cancer: In Sweden, nation-wide data on the principle reasons for a diagnosis of PC are available from 2004 onwards (National quality register for prostate cancer, https://statistik.incanet.se/npcr/ (accessed on 22 June 2023)); 28.6% of patients were non-symptomatic men diagnosed due to elevated PSA levels, and this proportion increased to 52.9% in 2020.