Significantly, the application of GO-Elite to the analysis of patients’ cohorts with grade III HCC (accession number GSE45050; [21]) identified a significant enrichment for genes associated to YY1, NRF1, and FOXP3 transcription factors (Supplementary Figure S7A,B), indicating that modulations of similar changes might be extrapolated through the analysis of the whole liver. Here, NRF1 is linked to hepatocellular carcinoma.