The ovarian cancer cell lines included human chemoresistant A2780Res and several murine syngeneic HGSOC tumor lines with fallopian tubal origin and key genetic alterations found in patients: BPPNM (Brca1−/−; Trp53−/R172H; Pten−/−; Nf1−/−MycOE) and a series of KPCA (Trp53−/R172H; Ccne1OE; Akt2OE; KRASG12V) tumor lines with varying degrees of immunotherapeutic resistance [39,41]. The gene discussed is PTEN; the disease is ovarian carcinoma.