CGAS and cancer: In general, the different classes of conventional cancer therapies that have been linked with activation of the cGAS-STING signaling axis can be classified into three categories (Table 1), the chemical structures of which are shown in the Supplemental Table S1: (i) microtubule-targeting antimitotic agents, (ii) inhibitors of DDR enzymes that damage DNA indirectly, and (iii) agents that directly damage DNA.