Using the ATM inhibitor KU60019, Zhang et al. demonstrated a cooperative activity with radiotherapy to induce type I IFN signaling in human and mouse pancreatic cancer cell lines in a manner that was independent of cGAS-STING, but dependent on both TBK1 and the proto-oncogene tyrosine protein kinase SRC [111]. This evidence concerns the gene STING1 and familial pancreatic carcinoma.