TP53 and mesenchymal cell neoplasm: In 2015, the Asian Cancer Research Group published their own molecular classification of GC with associated prognostic differences: tumors with microsatellite instability (MSI), mesenchymal tumors (microsatellite-stable tumors with epithelial-to-mesenchymal transition phenotype (MSS/EMT)), and non-EMT MSS tumors that are p53+ and p53− [32].