To the best of our knowledge, this study is the first attempt to analyze and compare DMR in a monocentric CML population using standard (RT-qPCR) and highly sensitive methods, such as BCR::ABL1 transcript quantification via dPCR and LSC CD26+ detection and quantification. This evidence concerns the gene DPP4 and chronic myelogenous leukemia, BCR-ABL1 positive.