In the present preliminary study, we compared and examined the results obtained using three different methods of detecting MRD in CML: (i) BCR::ABL1 transcript quantification by RT-qPCR, (ii) the quantification of the same transcriptby dPCR, and (iii) the quantification of circulating LSC in patients in TFR or exhibiting a DMR. Here, BCR is linked to chronic myelogenous leukemia, BCR-ABL1 positive.