In the ER-negative basal-like breast cancer (BLBC), a breast cancer subtype enriched with the expression of mesenchymal genes and reduced expression of epithelial ones including E-cadherin [68], downregulation of CDH1 is mediated by ZEB1, which recruits DNMT1 (a DNA methyl-transferase enzyme) to the CDH1 promoter to maintain the methylation status in the promoter. The gene discussed is CDH1; the disease is breast cancer.