One of the underlying mechanisms in tumor resistance is the aberrant activation of PI3K/AKT pathways that upregulates the expression of ABC transporters (P-gp/ABCB1, MRP1/ABCC1, and BRCP/ABCG2), and pro-survival molecules such as Bcl-2 and IAPs [11,49]. The gene discussed is BCL2; the disease is neoplasm.