Among such systems, The Cancer Genome Atlas (TCGA) provides a comprehensive classification, categorizing endometrial cancers into four distinct genomic categories: POLE ultramutated (POLEmut), microsatellite instability hypermutated or mismatch repair deficiency (MSI-H or MMRd), somatic copy-number alteration low or non-specific molecular profiler (CNL or NSMP), and the somatic copy-number high or p53 abnormal (CNH or p53abn) [4]. The gene discussed is TP53; the disease is endometrial cancer.