A study by Wechsler et al. from 2022 showed that 90% of CD30+ T-cell lymphoproliferative disorders (29 cases of lymphomatoid papulosis, 20 cases of primary cutaneous ALCL) showed loss of at least one T-cell antigen, with loss of CD7 being the most common (86% of cases), followed by loss of CD5 and CD3 (28% and 26% of cases, respectively), but with overall preservation of CD2 expression (loss only in 10% of cases) [40]. This evidence concerns the gene TNFRSF8 and anaplastic large cell lymphoma.