NPM1 and anaplastic large cell lymphoma: In 2014, using whole-transcriptome sequencing, Velusamy et al. identified a chimeric fusion involving NPM1 (5q35) and TYK2 (19p13) that encodes an NPM1-TYK2 protein in 12.5% (4/32) of cases of primary cutaneous ALCL and 20% (3/15) of cases of lymphomatoid papulosis [58].