One of the first descriptions of primary cutaneous ALCL was presented by Berti et al. who, in 1989, described the case of a 74-year-old woman with an ulcerated cutaneous nodule in the gluteal region composed of neoplastic epithelioid cells, which were initially interpreted as a metastasis, but were positive by immunohistochemistry for CD45R0 (UCHL-1) and Ber-H2 (CD30). The gene discussed is TNFRSF8; the disease is anaplastic large cell lymphoma.