On the other hand, ARID1A deficiencies may open ways in the future to promote the cell death of tumor cells, as ARID1A loss impairs genome stability in the tumor cells with their already high mutational burden, by several mechanisms: base excision repair as well as mismatch repair are often impaired, and the formation of R-loops and DNA catenation occur more frequently. The gene discussed is ARID1A; the disease is neoplasm.