While both claudins -3 and -4 exhibited similar reaction percentages and patterns in both Barrett’s esophagus and adenocarcinoma cases, claudin-7 showed a different result, where all Barrett’s esophagus and low-grade dysplasia cases were reactive to claudin-7 antibody, and the majority showed strong staining (Table 2) [24,27]. This evidence concerns the gene CLDN3 and adenocarcinoma.