CRP and neoplasm: In addition, in univariate analysis, a higher number of metastatic sites, the presence of brain metastases, an increase in lactate dehydrogenase (LDH) or C-reactive protein (CRP) levels, lower albumin and absolute lymphocyte count, a higher neutrophil-to-lymphocyte ratio and increased circulating tumour deoxyribonucleic acid (DNA) levels are of interest.