The VDR rs7975232 (ApaI)-AA as well as GC rs7041-C and CYP24A1 rs6068816-TT polymorphisms could be a risk factor for lower OS as well as CYP24A1 rs6068816-TT for PFS in Caucasian patients diagnosed with CRC; however, further research performed in higher populations is needed to demonstrate it. Here, VDR is linked to colorectal carcinoma.