The familial forms of CRC genetic predisposition have been correlated with germline mutations or epimutations in mismatch repair (MMR) genes such as MLH1, MSH2, MSH6, and PMS2 for nonpolyposis cases and in APC and MUTYH for Adenomatous colonic polyposis with recessive inheritance [4,5]. This evidence concerns the gene APC and colorectal carcinoma.