LAMA5 and Leigh syndrome: rs63750539 in the MLH1 gene has been described in several types of cancer including CRC and LS, rs373141354 in the PPP1R13B gene is associated with melanoma according to the Genetic Association of Complex Diseases database, rs551763507 in the LAMA5 gene is correlated to neuroblastoma, rs76670455 in NLRP14 gene to leukemia, and rs763119571 in TAS2R19 is also described in CRC according to the Cancer Genome Interpreter database.