MLH1 and colorectal carcinoma: In addition, a cohort study reported that MLH1 is the most frequently mutated gene in early-onset sporadic CRC patients, exhibiting four pathogenic variations: c.C793T (p.R265C), c.C1029A (p.Y343X), c.C793T (p.R265C), and c.C1029A (p.Y343X) [29].