Of these 43 SVs of probable impactful, 5 SVs overlapped with 4 genes with likely impact, 4 in the HRLS group (2 SVs in RELN, 1 each for FOXP1 and RRAS2 genes), and 1 in the IRLS group for the IRS2 gene previously associated with multiple cancers, including CRC according to OncoKB Cancer Genes list database. The gene discussed is IRS2; the disease is colorectal carcinoma.