According to the results presented here, treatment with CR, SB alone, or their combination promoted apoptosis in HCC liver tissue, as shown by the elevated levels of the pro-apoptotic proteins Bax and caspase-3 and the decreased levels of Bcl-2, PARP, pro-caspase-3, and pro-caspase-9 in comparison to the HCC animals. Here, CASP9 is linked to hepatocellular carcinoma.