On the other hand, in a study by Zandee et al., 24u5HIAA levels greater than 10 times the upper limit of normal levels were associated with poor OS in a univariate model for patients with midgut NETs; however, other tumor markers, including CgA and NSE, and tumor grade were far more powerful predictors and 24u5HIAA lost its prognostic significance in the multivariate analysis [44]. This evidence concerns the gene CGA and neoplasm.