Examples include the dysregulated expression of nuclear genes such as dynamin 1 (DRP1), mitofusin 1 (MFN1) and 2 (MFN2) mitochondrial fusion and fission proteins, BCL2 inter-acting protein 3 (BNIP3), PTEN-induced kinase 1 (PINK1), and hypoxia inducible factor 1 (HIF1), observed in lung, bladder, and breast cancers [156,157]. The gene discussed is PINK1; the disease is breast carcinoma.