CPSF4 and hepatocellular carcinoma: We compared the mRNA expression levels of these proteins in 212 HCC and 50 PT tissues from the TCGA dataset and found that CPSF1, CPSF3, CPSF4, CPSF6, and CSTF2 were significantly upregulated in HCC (p < 0.001, fold change > 2, Figure 1b).