In multivariate analysis using logistic regression in 456 patients with CRC, undifferentiated type (odds ratio [OR], 0.269; 95% CI: 0.127–0.571; p = 0.001) and p53 mutation type (OR, 1.662; 95% CI: 1.042–2.651; p = 0.033) were independent predictive risk factors for HSP60 high expression in CRC. The gene discussed is TP53; the disease is colorectal carcinoma.