Five top-ranked kinases in digestive system cancer shown in Figure 5B and Figure 6B are WNK2 (importance score of 0.342), NUAK Family Kinase 2 (NUAK2, 0.239), NEK3 (0.194), STK39 (0.184), STK17A (0.137), and Dual Serine/Threonine and Tyrosine Protein Kinase (DSTYK, 0.134). The gene discussed is NUAK2; the disease is digestive system cancer.