In contrast, it was reported that perlecan interacts with a complex of sema3A, plexin-A1, and NRP-1 on the cell surface of prostate cancer cells and that cleavage of this complex by MMP-7 cell-cell bonds promotes the metastatic dissemination of prostate cancer cells (Table 1) (Figure 3) [46]. This evidence concerns the gene HSPG2 and Familial prostate cancer.