In univariate analysis, high ISS (p = 0.001), elevated serum β2-microglobulin (p = 0.004), creatinine clearance <30 mL/min (p = 0.000), grade 3–4 anemia at the onset of the disease (p = 0.009) and worse frailty score (p = 0.002) negatively impact on OS. This evidence concerns the gene HLA-G and anemia (phenotype).