RUNX2 and posterior cortical atrophy: The direct target of miR-375 in PCa tissues has not yet been identified, but it is known that miR-375 overexpression increases osteoprotegerin, RUNX2, osteopontin, and bone sialoprotein gene expression in LNCaP cells, modulating genes that are directly related to osteoblast differentiation and activity [102,103] (Table 1).