IGFBP5 and posterior cortical atrophy: Conditioned medium from the PCa androgen-independent PC-3 cell line induces the expression of the osteoclastogenesis-associated genes insulin-like growth factor-binding protein 5 (IGFBP-5), interleukin 6 (IL-6), monocyte chemoattractant protein 1 (MCP-1), and RANKL, promoting osteoclastogenesis in RAW 264.7 cells [51].