Wnt1-induced secreted protein 1 (WISP-1), an important regulator of bone development and repair [82], is highly secreted by osteoblasts and can regulate αvβ1 integrin, focal adhesion kinase (FAK), and p38 signaling pathways, leading to inhibition of miR-126 expression in PCa cells. This evidence concerns the gene CCN4 and posterior cortical atrophy.