MMP2 and posterior cortical atrophy: Local uptake may be mediated by differential integrin expression, as observed by Hoshino et al. [37], who demonstrated that α6β4 and α6β1 exosomal integrins mediate lung metastasis, whereas αvβ5 is associated with liver metastasis and αvβ6 regulates matrix metalloproteinase-2 (MMP2), promoting osteolytic processes in PCa bone metastasis [44].