NFKB1 and neoplasm: Likewise, miR-204-5p was demonstrated to act as a tumor suppressor in PCa bone metastasis by inhibiting NF-κB signaling via direct targeting of TRAF1, TGF-β activated kinase 1 binding protein 3 (TAB3), and mitogen-activated protein kinase 3 (MAP3K3) [109], which are responsible for maintaining sustained NF-κB activation [110,111].