Exosomes from murine PCa cells decrease the fusion and differentiation of monocytic osteoclast precursors to mature, multinucleated osteoclasts and also decrease osteoclast fusion and proliferation markers, such as dendritic cell-specific transmembrane protein (DCSTAMP), triiodothyronine receptor auxiliary protein (TRAP), cathepsin K, and MMP9 [53]. Here, CTSK is linked to posterior cortical atrophy.