Nevertheless, BRAF V600E mediates immune escape in melanoma through several mechanisms: (i) release of immunosuppressive mediators in the tumour microenvironment (TME), such as IL-6; (ii) alteration of the composition and phenotype of neighbouring cells; (iii) downregulation of melanoma differentiation antigens expression; and iv) downregulation of MHC molecules [50,54,55]. This evidence concerns the gene IL6 and melanoma.