As far as specific BRAF mutations concern, Van der Kooij and colleagues [34] analyzed 3985 patients with advanced melanoma: BRAF V600E mutation was more frequent in women (46% females versus 36% males) in all age groups analyzed; on the other hand, BRAF V600K mutation was prevalent in male patients (8% males versus 4% females) regardless of age. The gene discussed is BRAF; the disease is melanoma.