A transcriptomic analysis using scRNA-seq of the genes linked to poor prognosis in CRC patients showed that the majority of these genes accumulate in a particular cell type known as high-relapse cells (HRC), which have an associated gene signature enriched in genes related to cell migration and cell-to-cell adhesion, and that differentiated from LGR5+ stem cells [49]. Here, LGR5 is linked to colorectal carcinoma.