SAT1 and Familial prostate cancer: In another example of an anti-cancer effect resulting from disruption of l-methionine salvage, Affronti et al. showed that inhibition of MTAP, together with upregulation of spermidine/spermine N1-acetyltransferase (SSAT) activity, resulted in increased apoptosis in radical prostatectomy ex vivo explant prostate cancer samples [87].