The role of l-asparagine in the adaptation of the cancer cell to l-glutamine deprivation is further evidenced by (1) its capacity to upregulate the expression of glutamine synthetase (GLUL), (2) its capacity to suppress apoptosis under l-glutamine deprivation, and (3) its ability to activate mTORC1 activity [222,223]. Here, GLUL is linked to cancer.