The role of GDH in cancers is discussed below.l-Glutamine + H2O → l-glutamate + +NH4 Deamidation(1)l-Glutamate + α-keto acid ⇆ α-ketoglutarate + l-amino acid Transamination(8)l-Glutamate + NAD(P)+ + H2O ⇆ α-ketoglutarate + +NH4 + NAD(P)H (9). The gene discussed is GLUD1; the disease is cancer.