XBP1 and cancer: In addition to HNSC, high XBP1 expression also significantly increased the risk of death in two types of cancer patients (LGG, HR = 1.82; UVM, HR = 24.24) and reduced the risk of death in three types of cancer patients (OV, HR = 0.52; PCPG, HR = 0.17; SKCM, HR = 0.64) (Figure 1C).