In the study, the decreased expression of PPARγ in obese WAT trans-activates the uptake transporter Slc1a5; impaired PPARγ in obesity leads to the downregulation of SLC1A5 and decreased adipocyte uptake of glutamine and methionine (two epigenetic modulators), which disrupts Bmal1 [162]. This evidence concerns the gene PPARG and obesity due to melanocortin 4 receptor deficiency.