A Western blot analysis of sWAT samples from normal-weight, obese, and weight-loss (WL) donors revealed that the BMAL2 protein was solely elevated by WL compared to BMAL1; demonstrating that BMAL2 is a WL-regulated adipogenesis inhibitor may aid in the development of strategies to combat obesity [201]. Here, BMAL1 is linked to obesity due to melanocortin 4 receptor deficiency.