Since EGFR stimulation is involved in renal fibrosis in other conditions [41], and our histopathological observations indicate severe and irreversible kidney dysfunction in the long-term post-infection period [21], we investigated whether EGFR stimulation occurs in kidneys following acute and long-term post-SARS-CoV-2 infection using a surrogate mouse model. Here, EGFR is linked to renal fibrosis.